5 days of steroids in COPD exacerbation are enough

In this randomized, non-inferiority multi-center trial in 5 swiss teaching hospitals, 314 patients that presented to casualty with exacerbation of COPD were enrolled. They were treated with oral prednisolon for either 5 or 14 days.

Results showed that a 5-day treatment was non-inferior to a 14-day treatment with regard to re-exacerbation within 6 months but significantly reduced glucocorticoid exposure. As so often: Less is more!

Leuppi JD, et al. JAMA. 2013 Jun 5;309(21):2223-31

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